SCIENTIFIC PUBLICATIONS

Thiel, K., Mulaku, E., Dandapani, H., Nagy, C., Aro, E-M., Kallio, P. (2018) Translation efficiency of heterologous proteins is significantly affected by the genetic context of RBS sequences in engineered cyanobacterium Synechocystis sp. PCC 6803. Microbial Cell Factories 2/2018.
DOI: 10.1186/s12934-018-0882-2


Patrikainen, P., Carbonell, V., Thiel, K., Aro, E-M and Kallio, P. (2017) Comparison of orthologous cyanobacterial aldehyde deformylating oxygenases in the production of volatile C3-C7 alkanes in engineered E. coli. Metabolic Engineering Communications 5: 9-18.
DOI:10.1016/j.meteno.2017.05.001


Vuorijoki L, Kallio P, Aro E-M (2017) SRM dataset of the proteome of inactivated iron-sulfur cluster biogenesis regulator SufR in Synechocystis sp. PCC 6803. Data in Brief 11: 572-575.
DOI: 10.1016/j.dib.2017.03.012


Vuorijoki, L., Tiwari, A., Kallio, P. & Aro, EM. (2017) Inactivation of iron-sulfur cluster biogenesis regulator SufR in Synechocystis sp. PCC 6803 induces unique iron-dependent protein-level responses. Biochimica et Biophysica Acta - General Subjects. 1861(5 Pt A):1085-1098.
DOI: 10.1016/j.bbagen.2017.02.020


Thiel, K.; Vuorio, E.; Aro, EM. & Kallio, P (2017) The effect of enhanced acetate influx on Synechocystis sp. PCC 6803 metabolism. Microb Cell Fact 16(21): 1-12.
DOI: 10.1186/s12934-017-0640-x


Kämäräinen, J.; Huokko, T.; Kreula, S.; Jones, PR.; Aro, EM. & Kallio, P. (2016) Pyridine nucleotide transhydrogenase PntAB is essential for optimal growth and photosynthetic integrity under low-light mixotrophic conditions in Synechocystis sp. PCC 6803. New Phytol. 214(1): 194–204.
DOI: 10.1111/nph.14353


Carbonell, V., Vuorio, E., Aro, E-M., and Kallio, P. (2016) Sequence optimization of efe gene from P. syringae is not required for stable ethylene production in recombinant Synechocystis sp. pcc 6803. IJIRTS 4(1): 30–35.
ijirts.org/volume4issue1/IJIRTSV4I1006.pdf


Vuorijoki, L., Isojärvi, J., Kallio, P., Kouvonen, P., Aro, E-M., Corthals, G., Jones, P. R. and Muth-Pawlak, D. (2015) Development of a quantitative SRM-based proteomics method to study iron metabolism of Synechocystis sp. PCC 6803. J. Proteome Res. 15: 266-279.
DOI: 10.1021/acs.jproteome.5b00800


Menon, N., Pásztor, A., Menon, B.R.K., Kallio, P., Fisher, K., Akhtar, Leys, D., Jones, P.R., and Scrutton, N.S. (2015) A microbial platform for renewable propane synthesis based on a fermentative butanol pathway. Biotechnology for Biofuels 8:61 12p.
DOI: 10.1186/s13068-015-0231-1

Kallio, P., Pásztor, A., Thiel, K., Akhtar, M. K. & Jones, P. R. (2014) An engineered pathway for the biosynthesis of renewable ​propane. Nat Commun 5(4731): 1-8
DOI: 10.1038/ncomms5731


Pásztor, A.; Kallio, P.; Malatinszky*, D.; Akhtar, MK. & Jones*, PR. (2014) A synthetic O2-tolerant butanol pathway exploiting native fatty acid biosynthesis in Escherichia coli. Biotechnol Bioeng 112(1):120-128.
DOI: 10.1002/bit.25324


Kallio, P., Pásztor, A., Akhtar, M. K., Jones, P. R. (2014) Renewable jet fuel. Curr. Opin. Biotechnol. 26: 50–55 (review).
DOI: 10.1016/j.copbio.2013.09.006


Vuorijoki, L., Kallio, P., Jones, P. R. (2014) Engineering Photobiological H2-Production. Algal Biorefineries (1): 203-216 (review).
DOI: 10.1007/978-94-007-7494-0_8


Paananen, P., Patrikainen, P., Kallio, P., Mäntsälä, P., Niemi, J., Niiranen, L., and Metsä-Ketelä, M. (2013) Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis. Biochemistry 52(31): 5304–5314.
DOI: 10.1021/bi400712q


Kallio, P., Patrikainen, P., Belogurov, G.A., Mäntsälä, P., Yang, K., Niemi, J. and Metsä-Ketelä, M. (2013) Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE. Biochemistry 52(26): 4507–4516.
DOI: 10.1021/bi400381s


Patrikainen, P., Kallio, P., Fan, K., Klika, K.D., Shaaban, K.A., Mäntsälä, P., Rohr, J., Yang, K., Niemi, J. and Metsä-Ketelä. M. (2012) Tailoring Enzymes Involved in the Biosynthesis of Angucyclines Contain Latent Context-Dependent Catalytic Activities. Chemistry & Biology 19(5): 647-655.
DOI:10.1016/j.chembiol.2012.04.010


Siitonen, V., Blauenburg, B., Kallio, P., Mäntsälä, P. and Metsä-Ketelä, M. (2012) Discovery of a Novel Two-Component Monooxygenase SnoaW/SnoaL2 Involved in Nogalamycin Biosynthesis. Chemistry & Biology 119(5): 638-646.
DOI: 10.1016/j.chembiol.2012.04.009


Kallio, P., Patrikainen, P., Suomela, J-P., Mäntsälä, P., Metsä-Ketelä, M. and Niemi, J. (2011) Flavoprotein Hydroxylase PgaE Catalyses Two Consecutive Oxygen-Dependent Tailoring Reactions in Angucycline Biosynthesis. Biochemistry 50(24): 5535-5543.
DOI: 10.1021/bi200600k


Liljeblad, A., Kallio, P., Vainio, M., Niemi, J. and Kanerva, L. T. (2010) Formation and hydrolysis of amide bonds by lipase A from Candida antarctica; exceptional features. Org. Biomol. Chem. 8: 886-895.
DOI: 10.1039/B920939P


Kallio, P. (2008) Type II aromatic polyketide biosynthetic tailoring enzymes: diversity and adaptation in Streptomyces secondary metabolism. Annales Universitatis Turkuensis A I 386 (doctoral thesis).
abstract - download in .pdf (1.75Mb)


Kallio, P., Liu, Z., Mäntsälä, P., Niemi, J. and Metsä-Ketelä, M. (2008) Sequential action of two flavoenzymes PgaE and PgaM in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C. Chemistry & Biology 15(2): 157-166.
DOI:10.1016/j.chembiol.2007.12.011


Kallio, P., Liu, Z., Mäntsälä, P., Niemi, J. and Metsä-Ketelä, M. (2008) A nested gene in Streptomyces bacteria encodes a protein involved in quaternary complex formation. J Mol Biol. 375(5): 1212-1221.
DOI:10.1016/j.jmb.2007.11.044 


Koskiniemi, H., Metsä-Ketelä, M., Dobritzsch, D., Kallio, P., Korhonen, H., Mäntsälä, P., Schneider, G., Niemi, J.(2007) Crystal Structures of Two Aromatic Hydroxylases Involved in the Early Tailoring Steps of Angucycline Biosynthesis. J Mol Biol. 372(3), 633-648.
DOI:10.1016/j.jmb.2007.06.087


Kallio, P., Sultana, A., Niemi, J., Mäntsälä, P. and Schneider, G. (2006) Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity, J. Mol. Biol. 357(1), 210-220.
DOI:10.1016/j.jmb.2005.12.064


Sultana, A., Kallio, P., Jansson, A., Wang, J-S., Niemi, J., Mäntsälä, P. and Schneider, G. (2004) Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation EMBO J. 5;23(9):1911-1921.
DOI:10.1038/sj.emboj.7600201


Sultana, A., Kallio, P., Jansson, A., Wang, J-S., Niemi, J., Mäntsälä, P. and Schneider, G. (2004) Crystallization and preliminary crystallographic data of SnoaL, a polyketide cyclase in nogalamycin biosynthesis. Acta Crystallogr. D Biol. Crystallogr. 60(Pt 6):1118-2000.
DOI:10.1107/S090744490400705X

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